Molecule miR-335: a valuable aid against tumor development
Continuing discoveries of 2010, Dr. Roberta Benetti with colleagues at the University of Udine, found that some molecules block the proliferation of the tumor. These cells only attack diseased cells and have therefore targeted as a possible cure. In addition, since these molecules are produced directly by the body, are completely natural and do not have side effects. This discovery could be a key in the treatment of cancer, becoming a viable alternative to chemotherapy or radiation therapy, that have many serious side effects.
The study was published in the renowned journal Cancer Research of the American Association for Cancer Research. A statement of the University of Udine says:
‘In particular, this research has for the first time demonstrated that one of microRNA molecules, precisely the miR-335, is directly responsible for the control, the generation and functions dell’onco-suppressor Rb, gene involved in the protection of the development of tumors. In addition, the study shows that the expression of miR-335 affects directly in balancing the delicate balance of protection against tumor development, because it also strikes on the tumor suppressor p53 through an indirect influence, the effects of two basic proteins known to be deregulated in tumorigenesis.”
The research was conducted with the support of the Italian Association for Cancer Research (AIRC), and with the collaboration of Michael Scarola (PhD student), Stefan Schoeftner (an expert researcher Austrian) and Claudio Schneider, Professor of Biology at the University of Udine and director of the National Laboratory of the Interuniversity Consortium for Biotechnology (CIB).
In a message, Dr. Benetti states: “In terms of therapeutic applicability, the study on miR-335 is still far from clinical trials and none of us has ever dared to say that could replace chemotherapy. The steps to evaluate its effects are very long and we are now experimenting on mice. Of course, we followed up the discoveries of 2010, also deepening its role in stem cells and publishing a recent paper in which we find associated with this new miRNA a new pathway which seems especially active in tumors of germinal origin. We really hope to continue in the right direction but we absolutely are not to the point to be able to do promises.”
That said, we are glad that it’s an Italian research and hoped that these clinical trials really give the results that we are all waiting for years, against this disease to which we are powerless and that for centuries continues to claim millions of victims.
New fashions and the desire to have a body always youth and perfect has led people to resort more and more to cosmetic or plastic surgery. Obviously, between mammoplasty, facelifts and liposuction, women are the ones who undergo more to surgical procedures and, oddly enough, in recent years have increased also the demands for corrective actions towards the “private parts”.
Compared to 2011, in 2012 there was a 24% increase of the operations to the sexual organs, despite the high costs and risks deriving from such surgeries.
The most common (female) surgical procedures are:
Labioplasty – the reduction of small or big labia that is done for purely aesthetic reasons, in the name of the much-vaunted eternal youth.
Vaginoplasty – An intervention intended to tighten the vagina. It is used especially after childbirth, as a definitive act to treat the symptoms related to the relaxation of the perineal and vaginal canal, to improve its function and sexual activity, but also to give to the partner the feeling of having to deal with a teen-aged vagina.
Vulvar Rejuvenation – The objective of this surgery is to improve the external genitalia appearance. By injection of hyaluronic acid or fat in order to give a certain tone to the vulva. The “rejuvenation” can also interest mound and labia.
Hymenoplasty – Although the reconstruction of the hymen is required by women whose culture imposes the virginity for social or religious reasons, some women make recourse to this kind of surgery for pure ambition.
instead, operations are primarily aimed at the enlargement or augmentation surgery (phalloplasty) of penis, which increase the length or width of the penis.
Eduardo De Filippowas and will be remembered as a great actor of theater and cinema, but not everyone knows that, in addition to being a great playwright, he has also written numerous poems. I’m going to propose you the one entitled “Pensieri Miei” (My Thoughts or I think it should be more suitable to translate as Thoughts of mine), and even daring to translate it into English.
It’s a poem about our “thoughts” that, as Eduardo says, they often do not have the courage to come out intact (nude), like they are born. And even if they would do, at cost of their life, then there will be always someone who tries to “cover” them. You will certainly understand that it is a metaphor.
THOUGHTS OF MINE
Penziere mieje, levàteve sti panne,
stracciàtev’ ‘a cammisa, e ascite annuro.
Si nun tenite n’abito sicuro,
tanta vestite che n’avit’ ‘a fa?
Menàteve spugliate mmiez’ ‘a via,
e si facite folla, cammenate.
Si sentite strillà, nun ve fermate:
nu penziero spugliato ‘a folla fa.
Currite ncopp’ ‘a cimma ‘e na muntagna,
e quanno ‘e piede se sò cunzumate:
un’ànema e curaggio, e ve menate…
nzerrano ll’uocchie, primm’ ‘e ve menà!
Ca ve trovano annuro? Nun fa niente.
Ce sta sempe nu tizio canusciuto,
ca nun ‘o ddice… ca rimmane muto…
e ca ve veste, primm’ ‘e v’atterrà.
Thoughts of mine, take off your clothes
tear the shirt and outputs naked.
If you do not keep a precise dress,
why do you have so many clothes?
Go stripped out in the street,
and if it becomes crowded in, walk.
If you hear screaming, do not stop,
a nude thought attracts crowd.
Run over the top of a mountain,
and when your feet will be worn out:
with spirit and courage, throw yourself…
closing your eyes before jumping!
Do they find you nude? It does not matter.
There is always a known guy
who will say nothing… who will stay silent…
and who will dress you before burying.