Molecule miR-335: a valuable aid against tumor development
Continuing discoveries of 2010, Dr. Roberta Benetti with colleagues at the University of Udine, found that some molecules block the proliferation of the tumor. These cells only attack diseased cells and have therefore targeted as a possible cure. In addition, since these molecules are produced directly by the body, are completely natural and do not have side effects. This discovery could be a key in the treatment of cancer, becoming a viable alternative to chemotherapy or radiation therapy, that have many serious side effects.
The study was published in the renowned journal Cancer Research of the American Association for Cancer Research. A statement of the University of Udine says:
‘In particular, this research has for the first time demonstrated that one of microRNA molecules, precisely the miR-335, is directly responsible for the control, the generation and functions dell’onco-suppressor Rb, gene involved in the protection of the development of tumors. In addition, the study shows that the expression of miR-335 affects directly in balancing the delicate balance of protection against tumor development, because it also strikes on the tumor suppressor p53 through an indirect influence, the effects of two basic proteins known to be deregulated in tumorigenesis.”
The research was conducted with the support of the Italian Association for Cancer Research (AIRC), and with the collaboration of Michael Scarola (PhD student), Stefan Schoeftner (an expert researcher Austrian) and Claudio Schneider, Professor of Biology at the University of Udine and director of the National Laboratory of the Interuniversity Consortium for Biotechnology (CIB).
In a message, Dr. Benetti states: “In terms of therapeutic applicability, the study on miR-335 is still far from clinical trials and none of us has ever dared to say that could replace chemotherapy. The steps to evaluate its effects are very long and we are now experimenting on mice. Of course, we followed up the discoveries of 2010, also deepening its role in stem cells and publishing a recent paper in which we find associated with this new miRNA a new pathway which seems especially active in tumors of germinal origin. We really hope to continue in the right direction but we absolutely are not to the point to be able to do promises.”
That said, we are glad that it’s an Italian research and hoped that these clinical trials really give the results that we are all waiting for years, against this disease to which we are powerless and that for centuries continues to claim millions of victims.